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Conversely, UVB radiation enhances melanin synthesis by facilitating melanocyte differentiation and stimulating keratinocytes to release melanocyte-stimulating hormone (MSH), along with associated immunomodulatory factors and stem cell growth factors (92, 93)

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A P -value of less than 0.1 in the Cochrans Q -test or greater than 50% value in the I 2 value illustrated significant heterogeneity